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Roundup® brand agricultural herbicides (Roundup PowerMAX®, Roundup PowerMAX® II, and Roundup WeatherMAX®) are registered for pre-harvest use to kill weeds and terminate grain sorghum plants. Apply a Roundup brand agricultural herbicide when grain sorghum is at 30% moisture or less. Physiological maturity occurs when a "black layer" forms at the base of grain berries.
See what Roundup Ready PLUS has to say about pre-harvest grain sorghum weed control here.